Publications – Handa Lab

Connect with Dr. Handa on Google Scholar and ResearchGate.

Journal Articles

  1. Ekrem Ozkan, Arnab Mondal, Megan Douglass, Sean P Hopkins, Mark Garren, Ryan Devine, Rashmi Pandey, James Manuel, Priyadarshini Singha, James Warnock, Hitesh Handa. Bioinspired ultra-low fouling coatings on medical devices to prevent device-associated infections and thrombosis. Journal of Colloid and Interface Science, 2021.
  1. Hamid Asadi, Sama Ghalei, Hitesh Handa, Ramaraja P. Ramasamy. Cellulose nanocrystal reinforced silk fibroin coating for enhanced corrosion protection and biocompatibility of Mg-based alloys for orthopedic implant applications. Progress in Organic Coatings, 2021
  1. Arnab Mondal, Priyadarshini Singha, Megan Douglass, Lori Estes, Mark Garren, Lauren Griffin, Anil Kumar, and Hitesh Handa. A Synergistic New Approach Toward Enhanced Antibacterial Efficacy via Antimicrobial Peptide Immobilization on a Nitric Oxide-Releasing Surface.
    ACS Applied Materials & Interfaces 2021
  1. Sama Ghalei, Sean Hopkins, Megan Douglass, Mark Garren, Arnab Mondal, Hitesh Handa. Nitric oxide releasing halloysite nanotubes for biomedical applications. Journal of Colloid and Interface Science 2021
  1. Devine R, Douglass M, Ashcraft M, Tayag N, and Handa H. Development of Novel Amphotericin B-Immobilized Nitric Oxide-Releasing Platform for the Prevention of Broad-Spectrum Infections and Thrombosis. ACS Applied Materials & Interfaces 2021
  1. Ashcraft M, Douglass M, Chen Y, and Handa H. Combination strategies for antithrombotic biomaterials: an emerging trend towards hemocompatibility. Biomaterials Science 2021
  1. Roberts TR, Choi JH, Wendorff DS, Harea GT, Beely BM, Sieck KN, Douglass ME, Singha P, Dean JB, Handa H, and Batchinsky AI. Tethered Liquid Perfluorocarbon Coating for 72 Hour Heparin-Free Extracorporeal Life Support. ASAIO Journal 2021
  1. Asadi H, Suganthan B, Ghalei S, Handa H, and Ramasamy R. A multifunctional polymeric coating incorporating lawsone with corrosion resistance and antibacterial activity for biomedical Mg alloys. Progress in Organic Coatings 2021
  1. Ghalei S, Hopkins S, Douglass M, Garren M, Mondal A, and Handa H. Nitric oxide releasing halloysite nanotubes for biomedical applications. Journal of Colloid and Interface Science 2021
  1. Ghalei S, Li J, Douglass M, Garren M, and Handa H. Synergistic Approach to Develop Antibacterial Electrospun Scaffolds Using Honey and S-Nitroso-N-acetyl Penicillamine. ACS Biomaterials Science & Engineering 2021
  1. Garren M, Ashcraft M, Qian Y, Douglass M, Brisbois EJ, and Handa H. Nitric oxide and viral infection: Recent developments in antiviral therapies and platforms. Applied Materials Today 2020
  1. Ghalei S, Mondal A, Hopkins S, Singha P, Devine R, and Handa H. Silk Nanoparticles: A Natural Polymeric Platform for Nitric Oxide Delivery in Biomedical Applications. ACS Applied Materials & Interfaces 2020
  1. Zhu L, Pearson DW, Benoit SL, Xie J, Pant J, Yang Y, Mondal A, Handa H, Howe JY, Hung Y-C, Vidal JE, Maier RJ, and Zhao Y. Highly Efficient Antimicrobial Activity of CuxFeyOz Nanoparticles against Important Human Pathogens. Nanomaterials 2020
  1. Hopkins S, Pant J, Goudie M, Nguyen D, and Handa H. Electrospun Bioabsorbable Fibers Containing S-Nitrosoglutathione for Tissue Engineering Applications. ACS Applied Bio Materials 2020
  1. Ozkan E, Mondal A, Singha P, Douglass M, Hopkins S, Devine R, Garren M, Manuel J, Warnock J, and Handa H. Fabrication of Bacteria- and Blood-Repellent Superhydrophobic Polyurethane Sponge Materials. ACS Applied Materials & Interfaces 2020
  1. Estes L, Singha P, Singh S, Sakthivel T, Garren M, Devine R, Brisbois EJ, Seal S, and Handa H. Characterization of a nitric oxide (NO) donor molecule and cerium oxide nanoparticle (CNP) interactions and their synergistic antimicrobial potential for biomedical applications. Journal of Colloid and Interface Science 2020
  1. Mondal A, Devine R, Estes L, Manuel J, Singha P, Mancha J, Palmer M, and Handa H. Highly Hydrophobic Polytetrafluoroethylene Particle Immobilization via Polydopamine Anchor Layer on Nitric Oxide Releasing Polymer for Biomedical Applications. Journal of Colloid and Interface Science 2020
  1. Douglass M, Hopkins S, Pandey R, Singha P, Norman M, and Handa H. S‐Nitrosoglutathione‐Based Nitric Oxide‐Releasing Nanofibers Exhibit Dual Antimicrobial and Antithrombotic Activity for Biomedical Applications. Macromolecular Bioscience 2020
  1. Atwi K, Mondal A, Pant J, Cheng Z, El Hajj O, Ijeli I, Handa H, and Saleh R. Physicochemical properties and cytotoxicity of brown carbon produced under different combustion conditions. Atmospheric Environment 2020
  1. Thompson AJ, Ma LJ, Major T, Jeakle M, Lautner-Csorba O, Goudie MJ, Handa H, Rojas-Pena A, and Potkay JA. Assessing and improving the biocompatibility of microfluidic artificial lungs. Acta Biomateriala 2020
  1. Devine R, Goudie M, Singha P, Douglass M, Schmiedt CW, Brisbois EJ, and Handa H. Mimicking the Endothelium: Dual Action Heparinized Nitric Oxide Releasing Surface. ACS Applied Materials & Interfaces 2020, 12, 18, 20158-20171
  1. Pant J, Mondal A, Manuel J, Singha P, Mancha J, and Handa H. H2S‑Releasing Composite: a Gasotransmitter Platform for Potential Biomedical Applications. ACS Biomaterials Science & Engineering 2020, 6, 4, 2062-2071
  1. Homeyer KH, Singha P, Goudie MJ, and Handa H. S‐Nitroso‐N‐acetylpenicillamine impregnated endotracheal tubes for prevention of ventilator‐associated pneumonia.. Biotechnology and Bioengineering 2020, 1-10.
  1. Roberts TR, Garren M, Handa H, and Batchinsky AI. Toward an Artificial Endothelium: Development of Blood-Compatible Surfaces for Extracorporeal Life Support.. The Journal of Trauma and Acute Care Surgery 2020.
  1. Singha P, Goudie MJ, Liu Q, Hopkins SP, Brown N, Schmiedt CW, Locklin J, and Handa H. Multipronged Approach to Combat Catheter-Associated Infections and Thrombosis by Combining Nitric Oxide and a Polyzwitterion: a 7 Day In Vivo Study in a Rabbit Model. ACS Applied Materials & Interfaces 2020, 12, 8, 9070-9079.
  1. Gao S, Zhang W, Wang R, Hopkins SP, Spagnoli JC, Racin M, Bai L, Li L, Jiang W, Yang X, Lee C, Nagata K, Howerth EW, Handa H, Xie J, Ma Q, and Kumar A. Nanoparticless Encapsulating Nitrosylated Maytansine To Enhance Radiation Therapy. ACS Nano 2020, 14, 2, 1468-1481.
  1. Roberts TR, Harea GT, Singha P, Sieck KN, Beely BM, Wendorff DS, Choi JH, Ande S, Handa H, Batchinsky AI. Heparin-Free Extracorporeal Life Support Using Tethered Liquid Perfluorocarbon: A Feasibility and Efficacy Study. Asaio Journal 2019.
  1. Mondal A, Douglass M, Hopkins S, Singha P, Tran M, Handa H, and Brisbois E. Multifunctional S-Nitroso-N-acetylpenicillamine-Incorporated Medical-Grade Polymer with Selenium Interface for Biomedical Applications. ACS Appl. Mater. Interfaces 2019, 11, 38, 34652-34662.
  1. Pant J, Pedaparthi S, Hopkins S, Goudie M, Douglass M, and Handa H. Antibacterial and Cellular Response Toward a Gasotransmitter-Based Hybrid Wound Dressing. ACS Biomaterials Science & Engineering 2019.
  1. Devine R, Singha P, and Handa H. Versatile Biomimetic Medical Device Surface: Hydrophobin Coated, Nitric Oxide-Releasing Polymer for Antimicrobial and Hemocompatible Applications. RSC Biomaterials Science 2019, 7, 3438-3449.
  1. Douglass M, Goudie M, Pant J, Singha P, Hopkins S, Devine R, Schmiedt C, and Handa H. Catalyzed Nitric Oxide Release via Cu Nanoparticles Leads to an Increase in Antimicrobial Effects and Hemocompatibility for Short-Term Extracorporeal Circulation. ACS Applied Bio Materials 2019, 2, 6, 2539-2548.
  1. Homeyer K, Goudie M, Singha P, and Handa H. Liquid-Infused Nitric-Oxide-Releasing Silicone Foley Urinary Catheters for Prevention of Catheter-Associated Urinary Tract Infections. ACS Biomaterials Science & Engineering 2019, 5, 4, 2021-2029.
  1. Singha P, Workman CD, Pant J, Hopkins S, and Handa H. Zinc-oxide Nanoparticles Act Catalytically and Synergistically with Nitric Oxide Donors to Enhance Antimicrobial Efficacy. Journal of Biomedical Research Part A 2019, 107(7):1425-1433.
  1. Goudie M, Singha P, Hopkins S, Brisbois E, and Handa H. Active Release of an Antimicrobial and Antiplatelet Agent from a Nonfouling Surface Modification. ACS Applied Materials & Interfaces 2019, 11, 4, 4523-4530.
  1. Pant J, Sundaram J, Goudie M, Nguyen DT, and Handa H. Antibacterial 3D bone scaffolds for tissue engineering application. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2018, 1552-4973, 1552-4981.
  1. Hopkins S, Pant J, Goudie M, Schmiedt C, and Handa H. Achieving long-term biocompatible silicone via covalently immobilized S-nitroso-N-acetylpenicillamine (SNAP) that exhibits 4 months of sustained nitric oxide release. ACS Applied Materials & Interfaces 2018. 10(32):27316-27325 amp;
  1. Jones A, Pant J, Lee E, Goudie M, Gruzd A, Mansfield J, Mandal A, Sharma S, and Handa H. Nitric oxide-releasing antibacterial albumin plastic for biomedical applications. Journal of Biomedical Materials Research Part A 2018, 106, 6, 1535-1542.
  1. Stroganov V, Pant J, Stoychev G, Janke A, Jehnichen D, Fery A, Handa H, and Ionov L. 4D Biofabrication: 3D Cell Patterning Using Shape-Changing Films. Advanced Functional Materials 2018, 1706248.
  1. Grommersch B, Pant J, Hopkins S, Goudie M, Handa H. Bio-Templated Synthesis and Characterization of Mesoporous Nitric Oxide-Releasing Diatomaceous Earth Silica Particles. Applied Materials & Interfaces 2017, 10, 3, 2291-2301.
  1. Pant J, Goudie M, Chaji S, Johnson B, Handa H. Nitric oxide releasing vascular catheters for eradicating bacterial infection. Journal of Biomedical Materials Research Part B 2017, 106, 8, 2849-2857.
  1. Goudie M, Pant J, Handa H. Liquid-infused nitric oxide-releasing (LINORel) silicone for decreased fouling, thrombosis, and infection of medical devices. Scientific Reports 2017.7, 1, 13623.
  1. Liu Q, Singha P, Locklin J, Handa H. Covalent Grafting of Antifouling Phosphorylcholine-Based Copolymers with Antimicrobial Nitric Oxide Releasing Polymers to Enhance Infection-Resistant Properties of Medical Device Coatings. Langmuir 2017:33, 45, 13105-13113.
  1. Pant J, Gao J, Goudie M, Hopkins S, Locklin J, Handa H. A Multi-defense Strategy: Enhancing Bactericidal Activity of a Medical Grade Polymer with a Nitric Oxide Donor and Surface-immobilized Quaternary Ammonium Compound. Acta Biomaterialia 201758:421-431.
  1. Pant J, Goudie M, Hopkins S, Brisbois E, Handa H. Tunable Nitric Oxide Release from S-nitroso-N-acetylpenicillamine via Catalytic Copper Nanoparticles for Biomedical Applications. ACS Applied Materials & Interfaces 2017, 9(18), pp 15254-15264.
  1. Singha P, Pant J, Goudie M, Workman C, Handa H. Enhanced Antibacterial Efficacy of Nitric Oxide Releasing Thermoplastic Polyurethanes with Antifouling Hydrophilic Topcoats. RSC Biomaterials Science 2017,5(7):1246-1255.
  1. Thompson A, Marks L, Goudie, M, Rojas-Pena A, Handa H, Potkay J. A Small-Scale, Rolled-Membrane Microfluidic Artificial Lung Designed Towards Future Large Area Manufacturing. Biomicrofluidics 2017; 11(2), 024113.
  1. Norton D, Fan N, Goudie M, Handa H, Platt M, Averett R. Computational Imaging Analysis of Glycated Fibrin Gels Reveals Aggregated and Anisotropic Structures. Journal of Biomedical Materials Research Part A 2017;105(8):2191-2198.
  1. Singha P, Locklin J, Handa H. A Review of the Recent Advances in Antimicrobial Coatings for Urinary Catheters. Acta Biomaterialia 2016;50:20-40.
  1. Brisbois EJ, Kim M, Wang X, Mohammed A, Major TC, Wu J, Brownstein J, Xi C, Handa H, Meyerhoff ME. Improved Hemocompatibility of Multi-Lumen Catheters via Nitric Oxide (NO) Release from S-Nitroso-N-acetylpenicillamine (SNAP) Composite Filled Lumen. ACS Applied Materials & Interfaces 2016; 8(43), 29270-29279.
  1. Goudie MJ, Brainard BM, Schmeidt CW, Handa H. Characterization and In Vivo Performance of Nitric Oxide-Releasing Extracorporeal Circuits in a Feline Model of Thrombogenicity. Journal of Biomedical Materials Research Part A 2016;105(2):539-546.
  1. Brisbois EJ, Major TC, Goudie MJ, Meyerhoff ME, Bartlett RH, Handa H. Attenuation of thrombosis and bacterial infection using dual function nitric oxide releasing central venous catheters in a 9 day rabbit model. Acta Biomaterialia 2016; 44, 304-312.
  1. Goudie MJ, Brisbois EJ, Pant J, Thompson A, Potkay JA, Handa H. Characterization of an S-nitroso-N-acetylpenicillamine-based nitric oxide releasing polymer from a translational perspective. International Journal of Polymeric Materials and Polymeric Biomaterials 2016; 65, 769-778.
  1. Sundaram J, Pant J, Goudie MJ, Mani S, Handa H. Antimicrobial and physiochemical characterization of biodegradable, nitric oxide-releasing nanocellulose-chitosan packaging membranes. ACS Journal of Agriculture and Food Chemistry 2016; 64(25), 5260-5266.
  1. Gao J, Huddlestone NE, White EM, Pant J, Handa H, Locklin J. Surface Grafted Antimicrobial Polymer Networks with high abrasion resistance. ACS Biomaterials Science & Engineering 2016; 2, 1169-1179.
  1. Goudie MJ, Ghuman AP, Collins SB, Pidaparti RM, Handa H. Investigation of diffusion characteristics through microfluidic channels for passive drug delivery applications. Journal of Drug Delivery 2016; Article ID 7913616.
  1. Brisbois EJ, Major TC, Goudie MJ, Bartlett RH, Meyerhoff ME, Handa H. Improved hemocompatibility of silicone rubber extracorporeal tubing via solvent swelling-impregnation of S-nitroso-N-acetylpenicillamine (SNAP) and evaluation in rabbit thrombogenicity model. Acta Biomaterialia 2016; 37, 111-119.
  1. Pant J, Goudie MJ, Brisbois EJ, Handa H.  Chapter: Nitric oxide-releasing polyurethanes. Advances in Polyurethane Biomaterials. Elsevier 2016; 417-449.
  1. Yu J, Brisbois EJ, Handa H, Annich G, Meyerhoff ME, Bartlett RH, Major TC. The immobilization of a direct thrombin inhibitor to a polyurethane as a nonthrombogenic surface coating for extracorporeal circulation. Journal of Materials Chemistry B 2016; 4, 2264-2272.
  1. Brisbois EJ, Handa H, Meyerhoff ME.  Chapter: Recent advances in hemocompatible polymers for biomedical applications.  Advanced Polymers in Medicine. Springer 2015; 481-511.
  1. Brisbois EJ, Davis RP, Jones AM, Major TC, Bartlett RH, Meyerhoff ME, Handa H. Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep. Journal of Materials Chemistry B 2015; 3, 1639-1645.
  1. Brisbois EJ, Wu J, Bayliss J, Wang S, Xi W, Bartlett RH, Meyerhoff ME, Handa H. Optimized polymeric film-based nitric oxide delivery inhibits bacterial growth in a mouse burn wound model. Acta Biomaterilia 2014; 10(10), 4136-4142.
  1. Major TC, Handa H, Bartlett RH. Rabbit Thrombogenicity Model: An effective and affordable in vivo assay for polymer hemocompatibility. Journal of Biomaterials Application 2014; 29(4), 479-501.
  1. Major TC, Brisbois EJ, Jones A, Annich GM, Bartlett RH, Handa H.  The effect of a polyurethane coating incorporating both a thrombin inhibitor and nitric oxide on hemocompatibility in extracorporeal circulation. Biomaterials 2014; 35, 7271-7285.
  1. Suchyta DJ, Handa H, Meyerhoff M. A novel nitric oxide releasing heparin conjugate: Preparation and characterization of an agent with combined antiplatelet/anticoagulant activities. Molecular Pharmaceutics 2014; 11(2), 645-650.
  1. Handa H, Major TC, Brisbois EJ, Amoako KA, Meyerhoff ME Bartlett RH. Hemocompatibility comparison of biomedical grade polymers using a rabbit thrombogenicity model for preparing nitric oxide releasing nonthrombogenic surfaces. Journal of Materials Chemistry B 2014; 2, 1059-1067.
  1. Major TC, Handa H, Brisbois EJ, Annich GM, Reynolds MM, Meyerhoff ME, Bartlett RH.  The mediation of platelet quiescence by NO-releasing polymers via cGMP-induced serine 239 phosphorylation of vasodilator-stimulated phosphoprotein. Biomaterials 2013, 34(33):8086-96.
  1. Handa H, Brisbois EJ, Major TC, Refahiyat L, Amoako KA, Brant DO, Annich GM, Meyerhoff ME, Bartlett RH. In vitro and in vivo study of sustained nitric oxide release coating using diazeniumdiolate-doped poly(vinyl chloride) matrix with poly(lactic-co-glycolic acid) additive. Journal of Materials Chemistry B 2013; 1, 3578-3587.
  1. Brisbois EJ, Handa H, Major TC, Bartlett RH, Meyerhoff ME. Long-term nitric oxide release and elevated temperature stability with S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As polymer. Biomaterials 2013; 34, 6957-6966.
  1. Amoako KA, Montoya PJ, Major TC, Handa H, Brant DO, Meyerhoff ME, Bartlett RH, Cook KE. Fabrication and in vivo thrombogenicity testing of nitric oxide generating artificial lungs. Journal of Biomedical Materials Research Part A, 2013; DOI: 10.1002/JBM34655.
  1. Amoako KA, Archangeli C, Handa H, Major TC, Meyerhoff ME, Annich GM, Bartlett RH. Thromboresistance characterization of extruded nitric oxide-releasing silicone catheters. American Society for Artificial Internal Organs 2012; 58(3), 238-246.
  1. Major TC, Brant DO, Burney PC, Amoako KA,  Annich GM, Meyerhoff MH, Handa H, Bartlett RH. The hemocompatibility of a nitric oxide generating polymer that catalyzes S-nitrosothiol decomposition in an extracorporeal circulation model. Biomaterials 2011; 32 (26), 5957-5969.
  1. Major TC, Brant DO, Reynolds MM, Bartlett RH, Meyerhoff MH, Handa H, Annich GM. The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer. Biomaterials 2010; 31(10), 2736-2745.
  1. Handa H, Gurczynski S, Jackson MP, Mao G. Immobilization and molecular interactions between bacteriophage and lipopolysaccharide bilayers. Langmuir 2010; 26 (14), 12095–12103.
  1. Blacklock J, Torsten S, Handa H, You Y-z, Oupicky D, Mao G, Mohwald H. Cross-linked bioreducible layer-by-layer films for increased cell adhesion and transgene expression. Journal of Physical Chemistry B 2010; 114, 5283-5291.
  1. Khdair A, Handa H, Mao G, Panyam J. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance in vitro. European Journal of Pharmaceutics and Biopharmaceutics 2009; 71(2), 214-222.
  1. Kakade S, Manickam DS, Handa H, Mao G, Oupický D. Transfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles. International Journal of Pharmaceutics 2009; 365, 44-52.
  1. Salakhutdinov I, VandeVord P, Palyvoda O,  Matthew H, Tatagiri G, Handa H, Mao G, Auner GW, Newaz G. Fibronectin adsorption to nanopatterned silicon surfaces. Journal of Nanomaterials 2008; DOI: 10.1155/2008/543170.
  1. Handa H, Gurczynski S, Jackson MP, Auner G, Walker J, Mao G. Recognition of salmonella typhimurium by immobilized phage P22 monolayers. Surface Science 2008; 602, 1392-1400.
  1. Khdair A, Gerard B, Handa H, Mao G, Shekhar MPV, Panyam J. Surfactant-polymer nanoparticles enhance the effectiveness of anticancer photodynamic therapy. Molecular Pharmaceutics 2008; 5(5), 795-807.
  1. Blacklock J, Handa H, Manickam DS, Mao G, Mukhopadhyay A, Oupicky D. Disassembly of layer-by-layer films of plasmid DNA and reducible TAT polypeptide. Biomaterials 2007; 28, 117-124.
  1. Chavanpatil MD, Handa H, Mao G, Panyam. J. Incorporation of phospholipids enhances cellular uptake and retention of surfactant-polymer nanoparticles. Journal of Biomedical Nanotechnology 2007; 3, 291-296.
  1. Chen D, Handa H, Wan L, Mao G. Surface morphological evolution of ultrathin P4VP films and generation of ordered pattern on graphite. Macromolecular Rapid Communication 2007; 28, 1619-1623.
  1. Shahani K, Jonnalagadda S, Handa H, Mao G, Panyam J. Phospholipid nanoparticles: process optimization using fractional factorial design and atomic force microscopy. Journal of Biomedical Nanotechnology 2007; 3(4), 394-400.
  1. Chavanpatil MD, Khdair A, Patil Y, Handa H, Mao G, Panyam J. Polymer-surfactant nanoparticles for sustained release of water-soluble drugs. Journal of Pharmaceutical Sciences 2007; 96, 3379-3389.
  1.  Mao G, Chen D, Handa H, Dong W, Kurth DG, Möhwald H. The deposition and aggregation of aspirin molecules on a phospholipid bilayer pattern. Langmuir 2005; 21, 578-585.