Handa Biomaterials Lab - University of Georgia

Welcome to the Handa Biomaterials Research Group at the University of Georgia. Our lab is committed to developing biocompatible coatings for medical devices through highly translational and interdisciplinary research. We perform fundamental cell/protein surface interaction studies, novel biomaterial development and optimization, and material testing in animal models.  Due to the critical nature of our research field, we have received NIH, CDC, and VA funding. Our novel materials stand to decrease the morbidity, mortality, and hospitalization costs associated with medical devices by reducing fouling, thrombosis, and infection.

 Latest News

 

05/02/24: Rashmi’s paper entitled “N-Acetyl Cysteine-Decorated Nitric Oxide-Releasing Interface for Biomedical Applications” has been published by ACS Applied Materials & Interfaces. Congratulations, Rashmi!

05/01/24: Elaine’s paper entitled “In vivo assessment of dual-function submicron textured nitric oxide releasing catheters in a 7-day rabbit model” has been published by Acta Biomaterialia. Congratulations, Elaine!

04/05/24: Dr. Handa has received the UGA Research Foundation’s 2024 Creative Research Medal.

04/02/24:  Patrick received the College’s 2024 Brahm P. Verma Award for Academic & Leadership Excellence. Congratulations, Patrick!

03/11/24: Ezram’s paper entitled “Bioinspired superhydrophobic surfaces with silver and nitric oxide-releasing capabilities to prevent device-associated infections and thrombosis” has been accepted by the Journal of Colloid and Interface Science. Congratulations, Ezram! 

02/14/24: Rashmi has accepted a postdoc position at Texas A&M. Congratulations, Rashmi! 

02/10/24: Dr. Garren has received the UGA Graduate School’s 2024 Excellence in Research Award in Applied Sciences for his dissertation research. 

Recent Publications

 

Bioinspired superhydrophobic surfaces with silver and nitric oxide-releasing capabilities to prevent device assisted infections and thrombosis. Journal of Colloid and Interface Science. 2024; 664 928-937.

 

Instant clot forming and antibacterial wound dressings: Achieving hemostasis in trauma injuries with S-nitroso-N-acetylpenicillamine—tranexamic acid—propolis formulation. Journal of Biomedical Materials Research. 2024; 1-11.

 

N-Acetyl Cysteine-Decorated Nitric Oxide-Releasing Interface for Biomedical Applications. ACS Applied Materials & Interfaces. 2024; 16, 19, 24248-24260.

 

In vivo assessment of dual-function submicron textured nitric oxide releasing catheters in a 7-day rabbit model. Acta Biomaterials 180. 2024; 372-382.

 

Preventing Staphylococci Surgical Site Infections with a Nitric Oxide-Releasing Poly(lactic acid-co-glycolic acid) Suture Material. ACS Applied Bio Materials. 2024; 3086-3095.

 

“Reactive” Chemical Strategy to Attain Substrate Independent “Liquid‐Like” Omniphobic Solid Anti‐Biofouling Coatings. Advanced Functional Medicine. 2024; 2401387.

 

Engineering Nitric Oxide-Releasing Antimicrobial Dental Coating for Targeted Gingival Therapy.  ACS Applied Bio Materials. 2024; 2993-3004.

 

Varying material thickness of silicone rubber for tunable nitric oxide release.  J Biomed Mater Res. 2024; 112(2): e35377.

 

S‐Nitroso‐N‐acetylpenicillamine impregnated latex: A new class of barrier contraception for the prevention of intercourse‐associated UTIs. J Biomed Mater Res. 2024;112(2): e35371.

 

Enhanced antibacterial efficacy against antibiotic-resistant bacteria via nitric oxide-releasing ampicillin polymer substrates. Journal of Colloid and Interface Science. 2024; 653 1763-1774.

 

In Situ Photo-crosslinkable Hyaluronic Acid/Gelatin Hydrogel for Local Nitric Oxide Delivery. ACS Applied Materials & Interfaces 15 (42), 48930-48944.

 

Chemical Modification of Tiopronin for Dual Management of Cystinuria and Associated Bacterial Infections. ACS Applied Materials & Interfaces 15 (37), 43332-43344.

 

Nanoarchitectonics of nitric oxide releasing supramolecular structures for enhanced antibacterial efficacy under visible light irradiation. Journal of Colloid and Interface Science 640, 144-161.

 

Advances in nitric oxide-releasing hydrogels for biomedical applications. Current Opinion in Colloid & Interface Science, 101704.

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