Publications – Handa Lab

Connect with Dr. Handa on Google Scholar and ResearchGate.

Journal Articles

  1. Goudie M, Pant J, Handa H. Liquid-infused nitric oxide-releasing (LINORel) silicone for decreased fouling, thrombosis, and infection of medical devices. Scientific Reports 2017.
  1. Liu Q, Singha P, Locklin J, Handa H. Covalent Grafting of Antifouling Phosphorylcholine-Based Copolymers with Antimicrobial Nitric Oxide Releasing Polymers to Enhance Infection-Resistant Properties of Medical Device Coatings. Langmuir 2017.
  1. Pant J, Gao J, Goudie M, Hopkins S, Locklin J, Handa H. A Multi-defense Strategy: Enhancing Bactericidal Activity of a Medical Grade Polymer with a Nitric Oxide Donor and Surface-immobilized Quaternary Ammonium Compound. Acta Biomaterialia 2017.
  1. Pant J, Goudie M, Hopkins S, Brisbois E, Handa H. Tunable Nitric Oxide Release from S-nitroso-N-acetylpenicillamine via Catalytic Copper Nanoparticles for Biomedical Applications. ACS Applied Materials & Interfaces 2017, 9(18), pp 15254-15264.
  1. Singha P, Pant J, Goudie M, Workman C, Handa H. Enhanced Antibacterial Efficacy of Nitric Oxide Releasing Thermoplastic Polyurethanes with Antifouling Hydrophilic Topcoats. RSC Biomaterials Science 2017.
  1. Thompson A, Marks L, Goudie, M, Rojas-Pena A, Handa H, Potkay J. A Small-Scale, Rolled-Membrane Microfluidic Artificial Lung Designed Towards Future Large Area Manufacturing. Biomicrofluidics 2017; 11(2), 024113.
  1. Norton D, Fan N, Goudie M, Handa H, Platt M, Averett R. Computational Imaging Analysis of Glycated Fibrin Gels Reveals Aggregated and Anisotropic Structures. Journal of Biomedical Materials Research Part A 2017; (accepted).
  1. Singha P, Locklin J, Handa H. A Review of the Recent Advances in Antimicrobial Coatings for Urinary Catheters. Acta Biomaterialia 2016.
  1. Brisbois EJ, Kim M, Wang X, Mohammed A, Major TC, Wu J, Brownstein J, Xi C, Handa H, Meyerhoff ME. Improved Hemocompatibility of Multi-Lumen Catheters via Nitric Oxide (NO) Release from S-Nitroso-N-acetylpenicillamine (SNAP) Composite Filled Lumen. ACS Applied Materials & Interfaces 2016; 8(43), 29270-29279.
  1. Goudie MJ, Brainard BM, Schmeidt CW, Handa H. Characterization and In Vivo Performance of Nitric Oxide-Releasing Extracorporeal Circuits in a Feline Model of Thrombogenicity. Journal of Biomedical Materials Research Part A 2016.
  1. Brisbois EJ, Major TC, Goudie MJ, Meyerhoff ME, Bartlett RH, Handa H. Attenuation of thrombosis and bacterial infection using dual function nitric oxide releasing central venous catheters in a 9 day rabbit model. Acta Biomaterialia 2016; 44, 304-312.
  1. Goudie MJ, Brisbois EJ, Pant J, Thompson A, Potkay JA, Handa H. Characterization of an S-nitroso-N-acetylpenicillamine-based nitric oxide releasing polymer from a translational perspective. International Journal of Polymeric Materials and Polymeric Biomaterials 2016; 65, 769-778.
  1. Sundaram J, Pant J, Goudie MJ, Mani S, Handa H. Antimicrobial and physiochemical characterization of biodegradable, nitric oxide-releasing nanocellulose-chitosan packaging membranes. ACS Journal of Agriculture and Food Chemistry 2016; 64(25), 5260-5266.
  1. Gao J, Huddlestone NE, White EM, Pant J, Handa H, Locklin J. Surface Grafted Antimicrobial Polymer Networks with high abrasion resistance. ACS Biomaterials Science & Engineering 2016; 2, 1169-1179.
  1. Goudie MJ, Ghuman AP, Collins SB, Pidaparti RM, Handa H. Investigation of diffusion characteristics through microfluidic channels for passive drug delivery applications. Journal of Drug Delivery 2016; Article ID 7913616.
  1. Brisbois EJ, Major TC, Goudie MJ, Bartlett RH, Meyerhoff ME, Handa H. Improved hemocompatibility of silicone rubber extracorporeal tubing via solvent swelling-impregnation of S-nitroso-N-acetylpenicillamine (SNAP) and evaluation in rabbit thrombogenicity model. Acta Biomaterialia 2016; 37, 111-119.
  1. Pant J, Goudie MJ, Brisbois EJ, Handa H.  Chapter: Nitric oxide-releasing polyurethanes. Advances in Polyurethane Biomaterials. Elsevier 2016; 417-449.
  1. Yu J, Brisbois EJ, Handa H, Annich G, Meyerhoff ME, Bartlett RH, Major TC. The immobilization of a direct thrombin inhibitor to a polyurethane as a nonthrombogenic surface coating for extracorporeal circulation. Journal of Materials Chemistry B 2016; 4, 2264-2272.
  1. Brisbois EJ, Handa H, Meyerhoff ME.  Chapter: Recent advances in hemocompatible polymers for biomedical applications.  Advanced Polymers in Medicine. Springer 2015; 481-511.
  1. Brisbois EJ, Davis RP, Jones AM, Major TC, Bartlett RH, Meyerhoff ME, Handa H. Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep. Journal of Materials Chemistry B 2015; 3, 1639-1645.
  1. Brisbois EJ, Wu J, Bayliss J, Wang S, Xi W, Bartlett RH, Meyerhoff ME, Handa H. Optimized polymeric film-based nitric oxide delivery inhibits bacterial growth in a mouse burn wound model. Acta Biomaterilia 2014; 10(10), 4136-4142.
  1. Major TC, Handa H, Bartlett RH. Rabbit Thrombogenicity Model: An effective and affordable in vivo assay for polymer hemocompatibility. Journal of Biomaterials Application 2014; 29(4), 479-501.
  1. Major TC, Brisbois EJ, Jones A, Annich GM, Bartlett RH, Handa H.  The effect of a polyurethane coating incorporating both a thrombin inhibitor and nitric oxide on hemocompatibility in extracorporeal circulation. Biomaterials 2014; 35, 7271-7285.
  1. Suchyta DJ, Handa H, Meyerhoff M. A novel nitric oxide releasing heparin conjugate: Preparation and characterization of an agent with combined antiplatelet/anticoagulant activities. Molecular Pharmaceutics 2014; 11(2), 645-650.
  1. Handa H, Major TC, Brisbois EJ, Amoako KA, Meyerhoff ME Bartlett RH. Hemocompatibility comparison of biomedical grade polymers using a rabbit thrombogenicity model for preparing nitric oxide releasing nonthrombogenic surfaces. Journal of Materials Chemistry B 2014; 2, 1059-1067.
  1. Major TC, Handa H, Brisbois EJ, Annich GM, Reynolds MM, Meyerhoff ME, Bartlett RH.  The mediation of platelet quiescence by NO-releasing polymers via cGMP-induced serine 239 phosphorylation of vasodilator-stimulated phosphoprotein. Biomaterials 2013, 34(33):8086-96.
  1. Handa H, Brisbois EJ, Major TC, Refahiyat L, Amoako KA, Brant DO, Annich GM, Meyerhoff ME, Bartlett RH. In vitro and in vivo study of sustained nitric oxide release coating using diazeniumdiolate-doped poly(vinyl chloride) matrix with poly(lactic-co-glycolic acid) additive. Journal of Materials Chemistry B 2013; 1, 3578-3587.
  1. Brisbois EJ, Handa H, Major TC, Bartlett RH, Meyerhoff ME. Long-term nitric oxide release and elevated temperature stability with S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As polymer. Biomaterials 2013; 34, 6957-6966.
  1. Amoako KA, Montoya PJ, Major TC, Handa H, Brant DO, Meyerhoff ME, Bartlett RH, Cook KE. Fabrication and in vivo thrombogenicity testing of nitric oxide generating artificial lungs. Journal of Biomedical Materials Research Part A, 2013; DOI: 10.1002/JBM34655.
  1. Amoako KA, Archangeli C, Handa H, Major TC, Meyerhoff ME, Annich GM, Bartlett RH. Thromboresistance characterization of extruded nitric oxide-releasing silicone catheters. American Society for Artificial Internal Organs 2012; 58(3), 238-246.
  1. Major TC, Brant DO, Burney PC, Amoako KA,  Annich GM, Meyerhoff MH, Handa H, Bartlett RH. The hemocompatibility of a nitric oxide generating polymer that catalyzes S-nitrosothiol decomposition in an extracorporeal circulation model. Biomaterials 2011; 32 (26), 5957-5969.
  1. Major TC, Brant DO, Reynolds MM, Bartlett RH, Meyerhoff MH, Handa H, Annich GM. The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer. Biomaterials 2010; 31(10), 2736-2745.
  1. Handa H, Gurczynski S, Jackson MP, Mao G. Immobilization and molecular interactions between bacteriophage and lipopolysaccharide bilayers. Langmuir 2010; 26 (14), 12095–12103.
  1. Blacklock J, Torsten S, Handa H, You Y-z, Oupicky D, Mao G, Mohwald H. Cross-linked bioreducible layer-by-layer films for increased cell adhesion and transgene expression. Journal of Physical Chemistry B 2010; 114, 5283-5291.
  1. Khdair A, Handa H, Mao G, Panyam J. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance in vitro. European Journal of Pharmaceutics and Biopharmaceutics 2009; 71(2), 214-222.
  1. Kakade S, Manickam DS, Handa H, Mao G, Oupický D. Transfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles. International Journal of Pharmaceutics 2009; 365, 44-52.
  1. Salakhutdinov I, VandeVord P, Palyvoda O,  Matthew H, Tatagiri G, Handa H, Mao G, Auner GW, Newaz G. Fibronectin adsorption to nanopatterned silicon surfaces. Journal of Nanomaterials 2008; DOI: 10.1155/2008/543170.
  1. Handa H, Gurczynski S, Jackson MP, Auner G, Walker J, Mao G. Recognition of salmonella typhimurium by immobilized phage P22 monolayers. Surface Science 2008; 602, 1392-1400.
  1. Khdair A, Gerard B, Handa H, Mao G, Shekhar MPV, Panyam J. Surfactant-polymer nanoparticles enhance the effectiveness of anticancer photodynamic therapy. Molecular Pharmaceutics 2008; 5(5), 795-807.
  1. Blacklock J, Handa H, Manickam DS, Mao G, Mukhopadhyay A, Oupicky D. Disassembly of layer-by-layer films of plasmid DNA and reducible TAT polypeptide. Biomaterials 2007; 28, 117-124.
  1. Chavanpatil MD, Handa H, Mao G, Panyam. J. Incorporation of phospholipids enhances cellular uptake and retention of surfactant-polymer nanoparticles. Journal of Biomedical Nanotechnology 2007; 3, 291-296.
  1. Chen D, Handa H, Wan L, Mao G. Surface morphological evolution of ultrathin P4VP films and generation of ordered pattern on graphite. Macromolecular Rapid Communication 2007; 28, 1619-1623.
  1. Shahani K, Jonnalagadda S, Handa H, Mao G, Panyam J. Phospholipid nanoparticles: process optimization using fractional factorial design and atomic force microscopy. Journal of Biomedical Nanotechnology 2007; 3(4), 394-400.
  1. Chavanpatil MD, Khdair A, Patil Y, Handa H, Mao G, Panyam J. Polymer-surfactant nanoparticles for sustained release of water-soluble drugs. Journal of Pharmaceutical Sciences 2007; 96, 3379-3389.
  1.  Mao G, Chen D, Handa H, Dong W, Kurth DG, Möhwald H. The deposition and aggregation of aspirin molecules on a phospholipid bilayer pattern. Langmuir 2005; 21, 578-585.


  1. Handa H, Grommersch B, Pant J, Goudie M, Hopkins S.  Bio-Templated Synthesis and Characterization of Mesoporous Nitric Oxide-Releasing Diatomaceous Earth Silica Particles. Application pending in the US Patent and Trademark Office, 2017
  1. Handa H, Pant J, Goudie M. Bioinspired wound dressing with highly effective antimicrobial potential. Application pending in the US Patent and Trademark Office, 2017
  1. Handa H, Singha P, Goudie M, Hopkins S. Surface Immobilized Nitric Oxide Donor for Multi-Functional Non-Fouling, Antithrombotic, and Bactericidal Surfaces. Application pending in the US Patent and Trademark Office, 2017
  1. Locklin J, Singha P, Liu Q, Handa H. Photochemically attached, permanent attachment of anti-fouling and anti-fogging coatings onto any surface. Application pending in the US Patent and Trademark Office, 2017
  1. Goudie MJ, Pant, J, Handa H. Nitric oxide releasing liquid infused materials for antibacterial and blood contacting applications. Application pending in the US Patent and Trademark Office, 2016
  1. Brisbois EJ, Kim M, Wang X, Meyerhoff ME, Bartlett RH, Handa H. Nitric oxide-releasing polymer filling for biomedical tubing applications. Application pending in the US Patent and Trademark Office, 2016.
  1. Sundaram J, Pant J, Goudie MJ, Mani S, Handa H. Nitric oxide-releasing packaging membranes. Application pending in the US Patent Trademark Office, 2016.
  1. Handa H, Bartlett RH, Meyerhoff ME, Brisbois EJ, Refahiyat L. Sustained nitric oxide release coating using diazeniumdiolate-doped polymer matrix with ester capped poly(lactic-co-glycolic acid) additive. Application pending in the US Patent and Trademark Office, 2012.
  1. Brisbois EJ, Handa H, Meyerhoff ME. Thromboresistant/bactericidal S-nitroso-N-acetylpenicillamine (SNAP)-doped nitric oxide release polymers with enhanced stability. US Patent 20,150,366,831; Dec. 2015.